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41.
Since it was first detected in 1999, West Nile virus (WNV) quickly spread, becoming the dominant vector-borne disease in North
America. Sometimes fatal to humans, WNV is even more widespread among birds, with hundreds of species known to be susceptible
to WNV infection in North America alone. However, despite considerable mortality and local declines observed in American crows
(Corvus brachyrhynchos), there has been little evidence of a large regional association between WNV susceptibility and population declines of any
species. Here we demonstrate a correlation between susceptibility to WNV measured by large-scale testing of dead birds and
two indices of overall population change among bird species following the spread of WNV throughout California. This result
was due primarily to declines in four species of Corvidae, including all species in this family except common ravens (Corvus corax). Our results support the hypothesis that susceptibility to WNV may have negative population consequences to most corvids on
regional levels. They also provide confirmation that dead animal surveillance programs can provide important data indicating
populations most likely to suffer detrimental impacts due to WNV. 相似文献
42.
A nationwide health card recording system for dairy cattle was introduced in Norway in 1975 (the Norwegian Cattle Health Services). The data base holds information on mastitis occurrences on an individual cow basis. A reduction in mastitis frequency across the population is desired, and for this purpose risk factors are investigated. In this paper a Bayesian proportional hazards model is used for modelling the time to first veterinary treatment of clinical mastitis, including both genetic and environmental covariates. Sire effects were modelled as shared random components, and veterinary district was included as an environmental effect with prior spatial smoothing. A non-informative smoothing prior was assumed for the baseline hazard, and Markov chain Monte Carlo methods (MCMC) were used for inference. We propose a new measure of quality for sires, in terms of their posterior probability of being among the, say 10% best sires. The probability is an easily interpretable measure that can be directly used to rank sires. Estimating these complex probabilities is straightforward in an MCMC setting. The results indicate considerable differences between sires with regards to their daughters disease resistance. A regional effect was also discovered with the lowest risk of disease in the south-eastern parts of Norway. 相似文献
43.
Evelyn Rodríguez-Estrada Mónica Fernández-Sánchez Jairo Muñoz-Delgado Ana Fresan-Orellana Gustavo Reyes-Terán 《Biological Rhythm Research》2016,47(1):1-6
The Steven–Johnson syndrome (SJS) is characterized by a sudden onset of mucous membrane erosion (predominantly oral mucosa, lips, and conjunctivae) with widespread blistering of the skin involving up to 10% of the body surface area. It is almost always a drug-related reaction, although it can be caused by infections and immunizations. A 33-year-old man with recent diagnosis of HIV infection developed antiretroviral treatment (ART)-associated SJS. Physical activity and sleep parameters were recorded by wrist actigraphy in four different consecutive scenarios: baseline assessment, first ART regimen, hospitalization, and second ART regimen. Significant differences were observed in physical activity patterns between the four phases. No differences in sleep parameters were found. To our knowledge, this is the first study recording physical activity changes and sleep during a SJS reaction. 相似文献
44.
M.A. Mena M.J. Casarejos J.A. Rodríguez-Navarro I. Rodal J.G. de Yebenes 《FEBS letters》2009,583(1):168-174
Parkin mutations produce Parkinson’s disease (PD) in humans and nigrostriatal dopamine lesions related to increased free radicals in mice. We examined the effects of NP7, a synthetic, marine derived, free radical scavenger which enters the brain, on H2O2 toxicity in cultured neurons and glia from wild-type (WT) and parkin null mice (PK-KO).NP7, 5-10 μM, prevented the H2O2 induced apoptosis and necrosis of midbrain neuronal and glial cultures from WT and PK-KO mice. NP7 suppressed microglial activation and the H2O2 induced drop-out of dopamine neurons. Furthermore, NP7 prevented the increased phosphorylation of ERK and AKT induced by H2O2. NP7 may be a promising neuroprotector against oxidative stress in PD. 相似文献
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46.
Andrew J. Sutherland-Smith 《Biophysical reviews》2011,3(1):15-23
The cytoskeleton framework is essential not only for cell structure and stability but also for dynamic processes such as cell migration, division and differentiation. The F-actin cytoskeleton is mechanically stabilised and regulated by various actin-binding proteins, one family of which are the filamins that cross-link F-actin into networks that greatly alter the elastic properties of the cytoskeleton. Filamins also interact with cell membrane-associated extracellular matrix receptors and intracellular signalling proteins providing a potential mechanism for cells to sense their external environment by linking these signalling systems. The stiffness of the external matrix to which cells are attached is an important environmental variable for cellular behaviour. In order for a cell to probe matrix stiffness, a mechanosensing mechanism functioning via alteration of protein structure and/or binding events in response to external tension is required. Current structural, mechanical, biochemical and human disease-associated evidence suggests filamins are good candidates for a role in mechanosensing. 相似文献
47.
BackgroundComparative evidence on the burden, trend, and risk factors of cancer is limited. Using data from the Global Burden of Disease (GBD) study, we aimed to assess cancer burden – incidence, prevalence, mortality, disability-adjusted life years (DALYs) – and attributable risk factors for Australia between 1990 and 2015, and to compare them with those of 34 members of the Organisation for Economic Co-operation and Development (OECD).MethodsThe general GBD cancer estimation methods were used with data input from vital registration systems and cancer registries. A comparative risk assessment approach was used to estimate the population-attributable fractions due to risk factors.ResultsIn 2015 there were 198,880 (95% uncertainty interval [UI]: 183,908–217,365) estimated incident cancer cases and 47,562 (95% UI: 46,061–49,004) cancer deaths in Australia. Twenty-nine percent (95% UI: 28.2–29.8) of total deaths and 17.0% (95% UI: 15.0–19.1) of DALYs were caused by cancer in Australia in 2015. Cancers of the trachea, bronchus and lung, colon and rectum, and prostate were the most common causes of cancer deaths. Thirty-six percent (95% UI: 33.1–37.9) of all cancer deaths were attributable to behavioral risks. The age-standardized cancer incidence rate (ASIR) increased between 1990 and 2015, while the age-standardized cancer death rate (ASDR) decreased over the same period. In 2015, compared to 34 other OECD countries Australia ranked first (highest) and 24th based on ASIR and ASDR, respectively.ConclusionThe incidence of cancer has increased over 25 years, and behavioral risks are responsible for a large proportion of cancer deaths. Scaling up of prevention (using strategies targeting cancer risk factors), early detection, and treatment of cancer is required to effectively address this growing health challenge. 相似文献
48.
Robert D. Jurmain 《American journal of physical anthropology》1980,53(1):143-150
Patterns of degenerative joint disease are investigated in the shoulder, elbow, hip, and knee joints of the macerated remains of approximately 800 individuals from 20th century American and two prehistoric populations. Age is an important contributory factor in all joints, but its effects are seen most directly in the shoulder and hip. Patterns of right-left involvement also indicate the elbow is the most susceptible area to local factors. Multiple joint involvement is seen more often in females from contemporary populations but more often in males from archeological groups. No significant association is found between degenerative involvement and osteometric measurements, and cause of death is probably only incidentally associated with degenerative disease. 相似文献
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